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Home >> Antibodies >> ORC1

ORC1

Mouse Monoclonal Antibody [Clone 7F6/1]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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SDS-PAGE Analysis Purified ORC1 Mouse Monoclonal Antibody (7F6/1). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

HSORC1; MmORC1; Origin Recognition Complex 1 (ORC1); Origin recognition complex subunit 1 (yeast homolog) like (ORC1L); Origin recognition complex subunit 1 like (S. cerevisia; Origin recognition complex subunit 1 like; PARC1; Replication control protein 1

Positive Control

HeLa cells.

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating, order antibody without BSA)Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human ORC1 protein

Cellular Localization

Nucleus.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

120kDa

Specificity & Comments

The initiation of DNA replication is a multi-step process that depends on the formation of pre-replication complexes, which trigger initiation. Among the proteins required for establishing these complexes are the origin recognition complex (ORC) proteins. ORC proteins bind specifically to origins of replication where they serve as scaffold for the assembly of additional initiation factors. Human ORC subunits 1-6 are expressed in the nucleus of proliferating cells and tissues, such as the testis. ORC1 and ORC2 are both expressed at equivalent concentrations throughout the cell cycle; however, only ORC2 remains stably bound to chromatin. ORC4 and ORC6 are also expressed constantly throughout the cell cycle. ORC2, ORC3, ORC4 and ORC5 form a core complex upon which ORC6 and ORC1 assemble. The formation of this core complex suggests that ORC proteins play a crucial role in the G1-S transition in mammalian cells.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Burke, T. W., et al. (2001). Journal of Biological Chemistry, 276(18), 15397-15408.
  2. Delobel, P., et al. (2006). The American Journal of Pathology, 168(3), 878-887.

Bioinformatics

  •  Entrez Gene ID: 4998
  •  Gene Symbol: ORC1L
  •  SwissProt: Q13415
  •  Chromosome Location: 1p32.3
  •  Unigene: 17908
NBT03067