2 Union Square, Union City, CA 94587
contact@NeoBiotechnologies.com
510-376-5603

Home >> Antibodies >> NEUROD2(Neurogenic Differentiation 2)(Transcription Factor)

NEUROD2(Neurogenic Differentiation 2)(Transcription Factor)

Mouse Monoclonal Antibody [Clone PCRP-NEUROD2-1G1]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
img

Flow cytometric analysis of PFA-fixed HeLa cells. NEUROD2 Mouse Monoclonal Antibody (PCRP-NEUROD2-1G1) followed by goat anti-mouse IgG-CF488 (blue); isotype control (red).

img

Immunofluorescence Analysis of PFA-fixed HeLa cells stained using NEUROD2 Mouse Monoclonal Antibody (PCRP-NEUROD2-1G1) followed by goat anti-mouse IgG-CF488 (green). CF640A phalloidin (red).

img

SDS-PAGE Analysis Purified NEUROD2 Mouse Monoclonal Antibody (PCRP-NEUROD2-1G1). Confirmation of Integrity and Purity of Antibody.

img

Analysis of Protein Array containing more than 19,000 full-length human proteins using NEUROD2 Mouse Monoclonal Antibody (PCRP-NEUROD2-1G1).

Product Details

Synonyms

bHLHa1; class A basic helix loop helix protein 1; NDR2; NDRF; NeuroD-related factor; NeuroD2; neurogenic basic helix loop helix protein; neurogenic differentiation 2; Neurogenic differentiation factor 2; neuronal differentiation 2

Positive Control

HeLa cells. Human brain.

Known Applications & Suggested Dilutions

ELISA, IP, Flow Cyt, IF         More Details

ELISA (For coating, order antibody without BSA)
Immunoprecipitation (1-2ug per 100-500ug of total protein (1ml of cell lysate))
Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human NEUROD2 protein

Cellular Localization

Nucleus.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

41kDa

Specificity & Comments

Members of the myogenic determination family are basic helix-loop-helix (bHLH) proteins that can be separated into two classes, both of which work together to activate DNA transcription. Class A proteins include the ubiquitously expressed E-box binding factors, namely E2A, ITF-2 and HEB, while class B proteins, such as MyoD, myogenin and Neuro D (2), are transiently expressed and exhibit a much more limited tissue distribution. Working in opposition to these positively acting factors are a specialized group of basic helix-loop-helix(bHLH) transcription factorsthat function as dominant negative regulators and are involved in cell lineage determination and differentiation. Neuro D2 (neurogenic differentiation 2), also known as NDRF, NEUROD2 or bHLHa1, is a 382 amino acid nuclear protein that contains one bHLH domain and functions to induce neurogenic differentiation, playing an important role in the maintenance and determination of cell fate.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Wang NP et. al. Am J Pathol 1995, 147:1799-1810.

Bioinformatics

  •  Entrez Gene ID: 4761
  •  Gene Symbol: NEUROD2
  •  SwissProt: Q15784
  •  Chromosome Location: 17q12
  •  Unigene: 322431