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Home >> Antibodies >> NACC1 / Nac1 / BTBD14B

NACC1 / Nac1 / BTBD14B

Mouse Monoclonal Antibody [Clone PCRP-NACC1-1A8]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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Flow Cytometric Analysis of PFA-fixed HeLa cells. NACC1 Mouse Monoclonal Antibody (PCRP-NACC1-1A8) followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).

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SDS-PAGE Analysis Purified NACC1 Mouse Monoclonal Antibody (PCRP-NACC1-1A8). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using NACC1 Mouse Monoclonal Antibody (PCRP-NACC1-1A8).

Product Details

Synonyms

BEND8; BTB Domain Containing 14B; BTB/POZ domain-containing protein 14B; btbd14b; NAC-1; NAC1; Nucleus accumbens-associated protein 1

Positive Control

HeLa, MCF7 or K562 cells.

Known Applications & Suggested Dilutions

Flow Cyt         More Details

Flow Cytometry (1-2ug/million cells)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human NACC1 protein

Cellular Localization

Nucleus. Cytoplasm. Distribution in the cytoplasm is dependent on phosphorylation.

Species Reactivity

Human

Host / Ig Isotype

Mouse / IgG2a

Mol. Weight of Antigen

57kDa

Specificity & Comments

The BTB (broad-complex, tramtrack and bric a brac) domain, also known as the POZ (poxvirus and zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. BTBD14B (BTB/POZ domain-containing protein 14B), also known as NACC1 (nucleus accumbens associated 1), BEND8 or NAC1, is a 527 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one BTB (POZ) domain. Existing as a homo-oligomer that interacts with HDAC3 and HDAC4, BTBD14B functions as a transcriptional repressor that influences the transcriptional activity of CRIF1 and is required for proteasome recruitment to the nucleus and cytoplasm in dendritic spines. BTBD14B is overexpressed in multiple carcinomas, suggesting a role in tumor development and metastasis.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Bardwell, V.J., et al. 1994. Genes Dev. 8: 1664-1677.
  2. Blackshaw S., et al. Nature methods15.5 (2018 May): 330-338.

Bioinformatics

  •  Entrez Gene ID: 112939
  •  Gene Symbol: NACC1
  •  SwissProt: Q96RE7
  •  Chromosome Location: 19p13.2
  •  Unigene: 531614