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Formalin-fixed, paraffin-embedded human brain stained with Myelin Basic Protein Rat Monoclonal Antibody (MBP/4273).
Formalin-fixed, paraffin-embedded human brain stained with Myelin Basic Protein Rat Monoclonal Antibody (MBP/4273).
SDS-PAGE Analysis Purified Myelin Basic Protein Rat Monoclonal Antibody (MBP/4273). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of human brain tissue lysate using Myelin Basic Protein Rat Monoclonal Antibody (MBP/4273).
Product Details
Synonyms
Positive Control
Known Applications & Suggested Dilutions
Immunogen
Cellular Localization
Species Reactivity
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Myelin basic protein (MBP) is the second most abundant protein in central nervous system (CNS) myelin: it comprises 30% of the total protein and about 10% of the dry weight of myelin. It is the only structural protein found so far to be essential for formation of CNS myelin, and has been called the executive molecule of myelin . MBP can interact with a number of polyanionic proteins including actin, tubulin, calmodulin, and clathrin, and negatively charged lipids, and acquires structure on binding to them. It may act as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. MBP may be applicable as a marker for oligodendrogliomas. MBP/4273 recognizes an epitope in the 82-87 region of MBP, useful in clinical diagnosis to detect MBP levels or myelination in human MBP. MBP/4273 is also used in a 2-site ELISA with clone MBP/4275. Both are used interchangeably as capture and detection antibody.
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