| Catalog Number: | 4155-MSM1 |
|---|---|
| Reactivity: | |
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Trial Size Available
Carrier-Free Available
Formalin-fixed, paraffin-embedded human brain stained with Myelin Basic Protein Mouse Monoclonal Antibody (MBP/4271).
Formalin-fixed, paraffin-embedded human brain stained with Myelin Basic Protein Mouse Monoclonal Antibody (MBP/4271).
SDS-PAGE Analysis of Purified Myelin Basic Protein Mouse Monoclonal Antibody (MBP/4271). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of human brain tissue lysate using Myelin Basic Protein Mouse Monoclonal Antibody (MBP/4271).
Western Blot Analysis of Human Brain, Mouse Brain, Rat Brain, Guinea pig Brain and Hamster Brain tissue lysates using Myelin Basic Protein Mouse Monoclonal Antibody (MBP/4271).
| Document Name | |
|---|---|
| Datasheet | Download Here |
| Material Safety Data Sheet | Download Here |
| Applications | Tested Dilutions | Protocol | Note |
|---|---|---|---|
| Immunohistochemistry (IHC) | 1-2ug/ml | IHC Protocol | 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes |
| Western Blot (WB) | 2-4ug/ml | Western Blot Protocol |
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Myelin basic protein (MBP) is the second most abundant protein in central nervous system (CNS) myelin: it comprises 30% of the total protein and about 10% of the dry weight of myelin. It is the only structural protein found so far to be essential for formation of CNS myelin, and has been called the executive molecule of myelin . MBP can interact with a number of polyanionic proteins including actin, tubulin, calmodulin, and clathrin, and negatively charged lipids, and acquires structure on binding to them. It may act as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. MBP may be applicable as a marker for oligodendrogliomas. MBP/4271 recognizes an epitope in the 129-138 region of MBP, useful in clinical diagnosis to detect MBP levels.
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