Home >> Antibodies >> MUC5AC (Mucin 5AC / Gastric Mucin)

MUC5AC (Mucin 5AC / Gastric Mucin)

Biotinylated Mouse Monoclonal Antibody [Clone 45M1]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab conjugated to Biotin; supplied with BSA and Azide at 200ug/ml

Purified Ab conjugated to Biotin; supplied WITHOUT BSA and Azide at 1.0mg/ml

Purified Ab conjugated to Biotin; supplied WITH BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab conjugated to Biotin; supplied with BSA and Azide at 200ug/ml

Purified Ab conjugated to Biotin; supplied WITHOUT BSA and Azide at 1.0mg/ml

Purified Ab conjugated to Biotin; supplied WITH BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Product Details

Synonyms

Apomucin Major Airway Glycoprotein, Mucin 5 subtype AC tracheobronchial, Mucin 5 Subtypes A And C, Mucin 5AC oligomeric mucus/gel forming, Tracheobronchial Mucin (TBM)

Positive Control

Stomach

Known Applications & Suggested Dilutions

Flow Cyt, IF, IHC-P More Details

Flow Cytometry (2-4ug/million cells)
Immunofluorescence (2-4ug/ml)
Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient

Cellular Localization

Cytoplasmic

Species Reactivity

Human, Monkey, Rabbit, Cat, Mouse, Rat, Pig, Hedgehog and Chicken. Does not react with cow.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

>1,000kDa

Specificity & Comments

This MAb recognizes the peptide core of gastric mucin M1 (recently identified as Mucin 5AC). �Its epitope is located in the C-terminal cysteine rich part of the peptide core of MUC5AC. Its epitope is destroyed by beta-mercaptoethanol but not by periodate treatment. This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.