SDS-PAGE Analysis Purified MMP3 Mouse Monoclonal Antibody (MMP3/2806). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human placenta stained with MMP3 Mouse Monoclonal Antibody (MMP3/2806). Inset: PBS instead of primary antibody; secondary only negative control.
Analysis of Protein Array containing more than 19,000 full-length human proteins using Monospecific MMP3 Mouse Monoclonal Antibody (MMP3/2806).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, 2 and 3, respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.