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MMP3 (Marker of Metastasis and Rheumatoid Arthritis) Antibody [MMP3/2655]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
4314-MSM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
4314-MSM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
4314-MSM5-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Western Blot (WB)
2-4ug/ml

Summary

The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, 2 and 3, respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Extracellular matrix, Extracellular space, Secreted
Gene Name
Positive Control
A431 cells. Prostate or Lung Carcinoma., HEK293, HT-29, Raji
Immunogen
Recombinant fragment of human MMP3 protein (around aa 236-363) (exact sequence is proprietary)
Alternate Names
Stromelysin-1, Matrix metalloproteinase-3, Transin-1, CHDS6; Matrix metalloproteinase 3; Matrix metalloproteinase-3; MMP3; Proteoglycanase; SL1; STMY1; STR1; Stromelysin-1; Transin 1

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
MMP3/2655
Chromosome Location
11q22.2
Mol. Weight of Antigen
57kDa

Functions

  • Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

Key References

  • Shur, S.A., et al. 1983. The role of cysteinyl residues in the phosphorylase kinase activity as revealed by iodacetamide modification. Biochem. Int. 7: 197-206

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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