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Home >> Antibodies >> Laminin Receptor/ RPSA (Marker of Metastatic Potential)

Laminin Receptor/ RPSA (Marker of Metastatic Potential)

Mouse Monoclonal Antibody [Clone RPSA/2699]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human breast carcinoma stained with Laminin Receptor Monospecific Mouse Monoclonal Antibody (RPSA/2699).

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Formalin-fixed, paraffin-embedded human colon carcinoma stained with Laminin Receptor Monospecific Mouse Monoclonal Antibody (RPSA/2699).

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Formalin-fixed, paraffin-embedded human cervical carcinoma stained with Laminin ReceptorMouse Monoclonal Antibody (RPSA/2699).

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Formalin-fixed, paraffin-embedded human tonsil stained with Laminin Receptor Mouse Monoclonal Antibody (RPSA/2699).

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Formalin-fixed, paraffin-embedded human basal cell carcinoma stained with Laminin Receptor Mouse Monoclonal Antibody (RPSA/2699).

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Immunofluorescentstaining of HeLa cells using Laminin Receptor Mouse Monoclonal Antibody (RPSA/2699)followed by goat anti-mouseIgG-CF488 (green).Nuclei are labeled with RedDot (red).

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Western blot analysis of humanTHP-1, U937, SK-BR3 and A431 cell lysates. Laminin Receptor Monospecific Mouse Monoclonal Antibody (RPSA/2699).

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SDS-PAGE Analysis Purified Laminin Receptor Mouse Monoclonal Antibody (RPSA/2699). Confirmation of Integrity and Purity of Antibody

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Flow Cytometric Analysis of PFA-fixed Raji cells. Laminin Receptor Monospecific Mouse Monoclonal Antibody (RPSA/2699) followed by goat anti-mouse IgG-CF488 (blue) and isotype control (red).

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Immunofluorescentstaining of PFA-fixedRaji cells using Laminin Receptor Mouse Monoclonal Antibody (RPSA/2699)followed by goat anti-mouse IgG-CF488 (green).Nuclei are labeled with RedDot (red).

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Laminin ReceptorMonospecific Mouse Monoclonal Antibody (RPSA/2699)

Product Details

Synonyms

34/67kDa Laminin Receptor;37kDa Laminin Receptor precursor;37/67kDa Laminin Receptor; 37LRP;40S Ribosomal Protein SA;67kDa Laminin Receptor; 67LR;Colon Carcinoma Laminin-binding Protein; LAMBR; Laminin receptor 1;Laminin-binding Protein precursor p40; LAMR1; LBP/p40; LRP/LR; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; Ribosomal Protein SA (RPSA)

Positive Control

MCF-7, MDA-MB-453or HEK293 cells.Human breast, colon or ovarian carcinoma.

Known Applications & Suggested Dilutions

Flow Cyt, IF, Western Blot, IHC-P         More Details

Flow Cytometry (1-2ug/ml)
Immunofluorescence (1-2ug/ml)
Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-lengthhuman RPSA protein

Cellular Localization

Cell Surface,Cytoplasmic and Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

37-67kDa

Specificity & Comments

Laminins, a family of extracellular matrix glycoproteins, are the major non-collagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. Reportedly, level of laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1mg/ml.

Key References

  1. W. Al-Saleh, et al.; J. Pathol.181, 287 (1997).

Bioinformatics

  •  Entrez Gene ID: 3921
  •  Gene Symbol: RPSA
  •  SwissProt: P08865
  •  Chromosome Location: 3p22.1
  •  Unigene: 449909