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Laminin Receptor/ RPSA (Marker of Metastatic Potential) Antibody [RPSA/2699]

In Stock
Catalog Number Formulation Size Price
3921-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
3921-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
3921-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-2ug/ml
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml

Summary

Laminins, a family of extracellular matrix glycoproteins, are the major non-collagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. Reportedly, level of laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cell membrane, Cytoplasm, Nucleus
Gene Name
Positive Control
colon or ovarian carcinoma., MCF-7, MDA-MB-453or HEK293 cells.Human breast
Immunogen
Recombinant full-lengthhuman RPSA protein
Alternate Names
40S ribosomal protein SA, 37 kDa laminin receptor precursor, 37/67 kDa laminin receptor, 67 kDa laminin receptor, Colon carcinoma laminin-binding protein, Laminin receptor 1, Laminin-binding protein precursor p40, Multidrug resistance-associated protein MGr1-Ag, NEM/1CHD4, Small ribosomal subunit protein uS2, 34/67kDa Laminin Receptor;37kDa Laminin Receptor precursor;37/67kDa Laminin Receptor; 37LRP;40S Ribosomal Protein SA;67kDa Laminin Receptor; 67LR;Colon Carcinoma Laminin-binding Protein; LAMBR; Laminin receptor 1;Laminin-binding Protein precursor p40; LAMR1; LBP/p40; LRP/LR; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; Ribosomal Protein SA (RPSA)

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
RPSA/2699
Chromosome Location
3p22.1
Mol. Weight of Antigen
37-67kDa

Functions

  • Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.
  • (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9.
  • (Microbial infection) Acts as a receptor for the Dengue virus.
  • (Microbial infection) Acts as a receptor for the Sindbis virus.
  • (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus.
  • (Microbial infection) Acts as a receptor for the pathogenic prion protein.
  • (Microbial infection) Acts as a receptor for bacteria.

Key References

  • W. Al-Saleh, et al.; J. Pathol.181, 287 (1997).

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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