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Immunofluorescent staining of HeLa cells using Laminin Receptor Mouse Monoclonal Antibody (RPSA/2699) followed by goat anti-mouseIgG-CF488 (green). Nuclei are labeled with RedDot (red).
Formalin-fixed, paraffin-embedded human cervical carcinoma stained with Laminin ReceptorMouse Monoclonal Antibody (RPSA/2699).
Formalin-fixed, paraffin-embedded human colon carcinoma stained with Laminin Receptor Monospecific Mouse Monoclonal Antibody (RPSA/2699).
Formalin-fixed, paraffin-embedded human tonsil stained with Laminin Receptor Mouse Monoclonal Antibody (RPSA/2699).
Formalin-fixed, paraffin-embedded human basal cell carcinoma stained with Laminin Receptor Mouse Monoclonal Antibody (RPSA/2699).
Formalin-fixed, paraffin-embedded human breast carcinoma stained with Laminin Receptor Monospecific Mouse Monoclonal Antibody (RPSA/2699).
Immunofluorescent staining of PFA-fixed Raji cells using Laminin Receptor Mouse Monoclonal Antibody (RPSA/2699) followed by goat anti-mouse IgG-CF488 (green). Nuclei are labeled with RedDot (red).
Flow Cytometric Analysis of PFA-fixed Raji cells. Laminin Receptor Monospecific Mouse Monoclonal Antibody (RPSA/2699) followed by goat anti-mouse IgG-CF488 (blue); isotype control (red).
SDS-PAGE Analysis of Purified Laminin Receptor Mouse Monoclonal Antibody (RPSA/2699). Confirmation of Integrity and Purity of Antibody.
Western blot analysis of human THP-1, U937, SK-BR3 and A431 cell lysates. Laminin Receptor Mouse Monoclonal Antibody (RPSA/2699).
Analysis of Protein Array containing more than 19,000 full-length human proteins using Laminin Receptor Monospecific Mouse Monoclonal Antibody (RPSA/2699). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Laminins, a family of extracellular matrix glycoproteins, are the major non-collagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. Reportedly, level of laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype.
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