2 Union Square, Union City, CA 94587

Home >> Antibodies >> Kappa Light Chain / IGKC (B-Cell Marker)

Kappa Light Chain / IGKC (B-Cell Marker)

Mouse Monoclonal Antibody [Clone KLC709]

Catalog #


0.5 ml at 100ug/ml

Price (USD)



Purified Ab conjugated to CF488

Catalog No


0.5 ml at 100ug/ml


Purified Ab conjugated to CF488

Price (USD)


Analysis of Protein Array containing more than 19,000 full-length human proteins using Kappa Light Chain (IGKC) Mouse Monoclonal Antibody (KLC709).

Product Details


HCAK1; Ig Kappa Chain C Region; IGKC; Immunoglobulin KM

Positive Control

293T, Raji or hPBL cells. Tonsil or Spleen.

Known Applications & Suggested Dilutions

Flow Cyt, IHC-P         More Details

Flow Cytometry (1-2ug/million cells)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.


Recombinant full-length human IGKC protein

Cellular Localization

Cell Surface, cytoplasmic and secreted

Species Reactivity


Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen


Specificity & Comments

This MAb is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. It recognizes human Ig kappa light chains of both secreted and cell surface immunoglobulin. It detects also free kappa light chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

Related Products

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Kiyotaki M et. al. J Immunol. 1987;138(12):4150-8.
  2. Nakamura T et. al. Proc Natl Acad Sci U S A. 1992;89(18):8522-6.


  •  Entrez Gene ID: 3514
  •  Gene Symbol: IGKC
  •  SwissProt: P01601, P01834
  •  Chromosome Location: 2p11.2
  •  Unigene: 449609