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Home >> Antibodies >> Kallikrein 5 (KLK5)

Kallikrein 5 (KLK5)

Mouse Monoclonal Antibody [Clone KLK5/3841]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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Formalin-fixed, paraffin-embedded human skin stained with Kallikrein 5 Mouse Monoclonal Antibody (KLK5/3841).

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SDS-PAGE Analysis Purified Kallikrein 5 Mouse Monoclonal Antibody (KLK5/3841). Confirmation of Integrity and Purity of Antibody

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Formalin-fixed, paraffin-embedded human skin stained with Kallikrein 5 Mouse Monoclonal Antibody (KLK5/3841).

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Kallikrein 5 Mouse Monoclonal Antibody (KLK5/3841)

Product Details

Synonyms

HK5; Kallikrein L2; Kallikrein like protein 2; Kallikrein related peptidase 5; Kallikrein-like protein 2 (KLKL2); Stratum corneum tryptic enzyme (SCTE)

Positive Control

Human skin tissue (IHC).

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human KLK5 protein (around aa 36-177) (exact sequence is proprietary)

Cellular Localization

Secreted

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2c, kappa

Mol. Weight of Antigen

33kDa

Specificity & Comments

Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Human pancreatic/renal KLK encodes for the KLK1 enzyme, which is involved in post-translational processing of polypeptide precursors. The function of the other members of KLK gene family is still currently unknown, but evidence suggests that many KLKs are implicated in carcinogenesis. The human KLK gene family consists of 15 serine proteases. The human KLK genes are clustered on chromosome 19q13. Unlike other kalllikreins, the KLK4-15 encoded proteases are less related and do not contain a conventional KLK loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression. KLK2 is also known as glandular kallikrein 2, tissue kallikrein, or HGK-1 and KLK3 is known as prostate-specific antigen (PSA). Both KLK2 and KLK3 have important applications in prostate cancer and breast cancer diagnostics. Many of the KLKs are regulated by steroid hormones and a few of them, specifically KLK3, KLK6 and KLK10, are known to be downregulated in breast and other cancers. KLK5 expression is abundant in skin, mammary gland and testis.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Diamandis, E.P., et al. 2000. The new human kallikrein gene family: implications in carcinogenesis. Trends Endocrinol. Metab. 11: 54-60.

Bioinformatics

  •  Entrez Gene ID: 25818
  •  Gene Symbol: KLK5
  •  SwissProt: Q9Y337
  •  Chromosome Location: 19q13.33
  •  Unigene: 50915
NBT03841