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Home >> Antibodies >> Interleukin-15 (IL-15)

Interleukin-15 (IL-15)

Mouse Monoclonal Antibody [Clone IL15/4354]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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Formalin-fixed, paraffin-embedded human adrenal gland stained with Interleukin-15 (IL-15) Mouse Monoclonal Antibody (IL15/4354). HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

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SDS-PAGE Analysis Purified IL-15 Mouse Monoclonal Antibody (IL15/4354). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing >19,000 full-length human proteins using Interleukin-15 (IL-15) Monospecific Mouse Monoclonal Antibody (IL15/4354).

Product Details

Synonyms

Interleukin-15 (IL-15); MGC9721

Positive Control

Human placenta, skeletal muscle or adrenal gland.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human IL15 (exact sequence is proprietary)

Cellular Localization

Secreted. Cytoplasm. Nucleus.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

14-15kDa

Specificity & Comments

Interleukin-15 (IL-15), also designated IL-T, is a cloned cytokine which shares several biological activities but no sequence homology with IL-2. Human, mouse and simian IL-15 cDNA clones have been isolated and characterized. All 3 species encode a 162 amino acid residue precursor protein containing a 48 amino acid leader that is cleaved to generate the mature form of IL-15. IL-15 stimulates the proliferation of T cells and NK cells, while enhancing B cell expansion and antibody production. Unlike IL-2, IL-15 is not produced by lymphocytes, but appears to be produced by macrophages, epithelial lines, muscle and placenta. IL-15 has also been shown to be a chemoattractant for human blood T lymphocytes and to be able to induce lymphokine-activated killer (LAK) activity in NK cells as well as to be able to induce the generation of cytolytic effector cells. Studies have shown that IL-15 is the only other cytokine that shares the signaling subunit of the IL-2R. Evidence also suggests that like IL-2, IL-4 and IL-7, IL-15 utilizes the common IL-2R subunit.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Wang, Hongsheng et al.The Journal of investigative dermatology vol. 140,9 (2020): 1824-1836.e7. doi:10.1016/j.jid.2020.01.026
  2. Reche PA, et al. Journal of Immunology. 2001;167(1):336 343. doi:10.4049/jimmunol.167.1.336

Bioinformatics

  •  Entrez Gene ID: 3600
  •  Gene Symbol: IL15
  •  SwissProt: IDP40933
  •  Chromosome Location: 4q31.21
  •  Unigene: 654378