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Home >> Antibodies >> Intelectin 1 / Omentin (Epithelioid-Type Malignant Mesothelioma Marker)

Intelectin 1 / Omentin (Epithelioid-Type Malignant Mesothelioma Marker)

Mouse Monoclonal Antibody [Clone ITLN1/4066]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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Formalin-fixed, paraffin-embedded human colon stained with Intelectin 1 / Omentin Mouse Monoclonal Antibody (ITLN1/4066).

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Intelectin 1 / Omentin Mouse Monoclonal Antibody (ITLN1/4066).

Product Details

Synonyms

Endothelial lectin HL-1; Galactofuranose binding lectin; hIntL; Intestinal lactoferrin receptor; INTL; ITLN; LFR

Positive Control

Human mesothelioma or colon tissue.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa16-141) of human Intelectin-1 (ITLN1) protein (exact sequence is proprietary)

Cellular Localization

Cell membrane. Secreted.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2c, kappa

Mol. Weight of Antigen

35kDa

Specificity & Comments

Human intelectin-1 (ITLN-1) is a novel identified galactose binding lectin that is usually expressed in the heart, small intestine, and colon. In normal tissues, human intelectin-1 was mainly secreted from gastrointestinal goblet cells along with mucus into the intestinal lumen, and it was also expressed, to a lesser extent, in mesothelial cells and urinary epithelial cells. It is overexpressed in human malignant pleural mesothelioma (MPM). In contrast, sarcomatoid-type MPMs, biphasic MPMs, and poorly differentiated MPMs are rarely positive for intelectin-1, and it is not expressed in other cancers, except in mucus-producing adenocarcinoma.

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200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Kuraoka, M., et al. (2017). Identification of DAB2 and Intelectin-1 as Novel Positive Immunohistochemical Markers of Epithelioid Mesothelioma by Transcriptome Microarray Analysis for Its Differentiation From Pulmonary Adenocarcinoma. The American Journal of Surgical Pathology, 41 (8): 1045-1052.
  2. Kota, W., et al. (2012). Specific Expression of Human Intelectin-1 in Malignant Pleural Mesothelioma and Gastrointestinal Goblet Cells. PLoS ONE 7(7): e39889.

Bioinformatics

  •  Entrez Gene ID: 55600
  •  Gene Symbol: ITLN1
  •  SwissProt: Q8WWA0
  •  Chromosome Location: 1q23.3
  •  Unigene: 50813