Learn about our comprehensive antibody validation methods to ensure monospecificity.  Antibody Validation>>

Intelectin 1 / Omentin (Epithelioid-Type Malignant Mesothelioma Marker) Antibody [ITLN1/4065]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
55600-MSM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
55600-MSM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
55600-MSM5-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Human intelectin-1 (ITLN-1) is a novel identified galactose binding lectin that is usually expressed in the heart, small intestine, and colon. In normal tissues, human intelectin-1 was mainly secreted from gastrointestinal goblet cells along with mucus into the intestinal lumen, and it was also expressed, to a lesser extent, in mesothelial cells and urinary epithelial cells. It is overexpressed in human malignant pleural mesothelioma (MPM). In contrast, sarcomatoid-type MPMs, biphasic MPMs, and poorly differentiated MPMs are rarely positive for intelectin-1, and it is not expressed in other cancers, except in mucus-producing adenocarcinoma.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Research Areas
Isotype / Light Chain
IgG2c / Kappa
Cellular Localization
Cell membrane, Secreted
Gene Name
Positive Control
Human mesothelioma or colon tissue.
Immunogen
Recombinant fragment (around aa16-141) of human Intelectin-1 (ITLN1) protein (exact sequence is proprietary)
Alternate Names
Intelectin-1, Endothelial lectin HL-1, Galactofuranose-binding lectin, Intestinal lactoferrin receptor, Omentin, Endothelial lectin HL-1; Galactofuranose binding lectin; hIntL; Intestinal lactoferrin receptor; INTL; ITLN; LFR

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
ITLN1/4065
Chromosome Location
1q23.3
Mol. Weight of Antigen
35kDa

Functions

  • Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499).

Key References

  • Kuraoka, M., et al. (2017). Identification of DAB2 and Intelectin-1 as Novel Positive Immunohistochemical Markers of Epithelioid Mesothelioma by Transcriptome Microarray Analysis for Its Differentiation From Pulmonary Adenocarcinoma. The American Journal of Surgical Pathology, 41 (8): 1045-1052.
  • Kota, W., et al. (2012). Specific Expression of Human Intelectin-1 in Malignant Pleural Mesothelioma and Gastrointestinal Goblet Cells. PLoS ONE 7(7): e39889.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

Reviews

There are no reviews yet.

Be the first to review “Intelectin 1 / Omentin (Epithelioid-Type Malignant Mesothelioma Marker) Antibody”

Your email address will not be published. Required fields are marked *

PARTNERSHIP OPPORTUNITIES

We hold Exclusive rights to 10,000 recombinant and hybridoma antibody products, available for Licensing or Collaboration.

LETS TALK