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Home >> Antibodies >> IGF1R / CD221

IGF1R / CD221

Mouse Monoclonal Antibody [Clone IGF1R/4667]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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Formalin-fixed, paraffin-embedded human colon carcinoma stained with IGF-1R / CD221 Mouse Monoclonal Antibody (IGF1R/4667).

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Formalin-fixed, paraffin-embedded human breast carcinoma stained with IGF-1R / CD221 Mouse Monoclonal Antibody (IGF1R/4667).

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Formalin-fixed, paraffin-embedded human prostate carcinoma stained with IGF-1R / CD221 Mouse Monoclonal Antibody (IGF1R/4667).

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SDS-PAGE Analysis Purified IGF-1R / CD221 Mouse Monoclonal Antibody (IGF1R/4667). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using CD221 / IGF1R Mouse Monoclonal Antibody (IGF1R/4667).

Product Details

Synonyms

CD221 antigen; IGF 1 receptor; IGF 1R; IGFIR; IGFIRC; IGFR; Insulin like growth factor 1 receptor precursor; Insulin-like growth factor 1 receptor beta chain; JTK13; Soluble IGF1R variant 1; Soluble IGF1R variant 2

Positive Control

Human breast carcinoma or colon carcinoma.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-4ug/ml)
In-vitro Neutralization of Biological Activity of IGF-1 (Order Ab without Azide)Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa550-750) of human IGF1R protein (exact sequence is proprietary)

Cellular Localization

Cell membrane.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2c, kappa

Mol. Weight of Antigen

130kDa (IGF-1R); 97kDa (IGF-1R); 200kDa (pro-IGF-1R)

Specificity & Comments

Receptor tyrosine kinases (RTKs) are transmembrane molecular scaffolds that influence cellular processes including the cell cycle, cell migration, cell metabolism, cell survival, proliferation and differentiation. Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand Insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of Insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. The human IGF-IR gene maps to chromosome 15q26.3 and encodes a 1,376 amino acid precursor protein that cleaves into and subunits. The human IGF-IIR gene maps to chromosome 6q26 and encodes a 2,491 amino acid transmembrane protein.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Yue, L., et al. 2012. Inhibition of hepatocellular carcinoma cell growth by an anti-Insulin-like growth factor-I receptor monoclonal antibody. Oncol. Rep. 28: 1453-1460.

Bioinformatics

  •  Entrez Gene ID: 3480
  •  Gene Symbol: IGF1R
  •  SwissProt: P08069
  •  Chromosome Location: 15q26.3
  •  Unigene: 643120, 714012