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IgA Secretory Component / ECM1

Mouse Monoclonal Antibody [Clone SC05]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded human colon carcinoma stained with Secretory Component Mouse Monoclonal Antibody (SC-05).

SDS-PAGE Analysis Purified Secretory Component Mouse Monoclonal Antibody (SC-05). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human colon carcinoma stained with Secretory Component Mouse Monoclonal Antibody (SC-05).

SDS-PAGE Analysis Purified Secretory Component Mouse Monoclonal Antibody (SC-05). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

ECM1, Extracellular Matrix Protein 1, Secretory Component p85, URBWD

Positive Control

Stomach, Lung, or Breast tumor.

Known Applications & Suggested Dilutions

Flow Cyt, IF, IHC-P More Details

Flow Cytometry (0.5-1ug/million cells)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Full length native protein (purified) corresponding to Human IgA Secretory Component. Affinity-purified secretory component from human colostrum.

Cellular Localization

Cell surface. Cytoplasm.

Species Reactivity

Human and Rat.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

~80kDa

Specificity & Comments

This MAb reacts with a reduction-resistant epitope present in both free and SIgA bound Secretory Component. It does not react with the cell lines lacking secretory component. The antibody is useful for studying the distribution and level of both free and bound secretory component. Secretory component is differentially expressed in epithelium, and the antibody is a popular marker for identifying subpopulations of epithelial cells and epithelial differentiation. The Secretory component antibody is a useful research tool for studying mucosal immunity, inflammation, remodeling, differentiation and tumorigenesis, all processes associated with differential secretory component expression.