Formalin-fixed, paraffin-embedded human cervix stained with E-Cadherin Rabbit RecombinantMonoclonal Antibody (CDH1/4398R).
Formalin-fixed, paraffin-embedded human stomach stained with E-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH1/4398R).
IHC analysis of formalin-fixed, paraffin-embedded human brain. Negative tissue control using CDH1/4398R at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.
Formalin-fixed, paraffin-embedded human cervix stained with E-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH1/4398R).
Analysis of Protein Array containing more than 19,000 full-length human proteins using E-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH1/4398R).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
E-cadherin is a transmembrane, calcium dependent cell adhesion protein that mediates cell to cell adhesion and maintains structural and functional integrity of epithelial tissues. It also has pivotal barrier functions and maintains the polarity of epithelial cells. Reduced or aberrant E-cadherin expression breaks cell to cell contacts, and thus, cells acquire the ability to migrate. In normal tissues, immunostaining of E-cadherin is localized to the membrane of epithelial cells, consistent with its role in cell adhesion. And in tumor tissues, E-cadherin stains positively in glandular epithelium as well as adenocarcinomas of the lung, gastrointestinal tract, and ovary. It has also been shown to be positive in some thyroid carcinomas. A combination of E-cadherin and p120 catenin may help distinguish ductal carcinoma of the breast from lobular carcinoma. And also, several studies have reported that reduced E-cadherin expression is correlated with poor prognosis in several types of carcinomas.