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Home >> Antibodies >> Desmocollin-2/3

Desmocollin-2/3

Recombinant Mouse Monoclonal Antibody [Clone rDSC2/3437]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified Desmocollin-2/3 Recombinant Mouse Monoclonal Ab (rDSC2/3437). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

ARVD11; Cadherin family member 2; CDHF2; Desmocollin-2; Desmocollin-3; Desmosomal glycoprotein II and III; Desmosomal glycoprotein II; Desmosomal glycoprotein III; DG2; DGII/III; DSC2; DSC3

Positive Control

HeLa cells. Skin tissue.

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating, order Ab without BSA)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human DSC2 protein

Cellular Localization

Cell surface

Species Reactivity

Human. Mouse. Rat.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

110kDa (DSC2); 100kDa (DSC3)

Specificity & Comments

Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. The desmosome is subdivided into two regions. The plaque region lies adjacent to the plasma, and is believed to contain molecules that attach the intermediate filament cytoskeleton to the desmosome. The core region is composed of transmembrane glycoproteins that are thought to mediate cell-cell adhesion. Desmogleins and desmocollins are the main desmosomal transmembrane proteins. These desmosomal glycoproteins belong to the members of the cadherin family of adhesion molecules. Three different isoforms of both desmogleins and desmocollins have been identified, named as desmoglein 1-3 and desmocollins. Desmosomal cadherins showed differentiation-specific expression in the human epidermis, although the functional significance of this differential expression is not fully understood. Desmocollin-1 can be found in the upper layers. The expression of desmocollin-2 varies in the basal and suprabasal layers. And desmocollin-3 is expressed more evenly throughout the suprabasal layers.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Buxton, RS., et al. Nomenclature of the desmosomal cadherins. J Cell Biol 1993, 121:481-483.

Bioinformatics

  •  Entrez Gene ID: 1824
  •  Gene Symbol: DSC2
  •  SwissProt: Q02487
  •  Chromosome Location: 18q12.1
  •  Unigene: 95612
NBT03437