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Home >> Antibodies >> CD61 / Integrin 3 / Platelet Glycoprotein IIIa (Platelet Marker)

CD61 / Integrin 3 / Platelet Glycoprotein IIIa (Platelet Marker)

Mouse Monoclonal Antibody [Clone ITGB3/2145]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human Tonsil stained with CD61 Mouse Monoclonal Antibody (ITGB3/2145).

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Formalin-fixed, paraffin-embedded human Spleen stained with CD61 Mouse Monoclonal Antibody (ITGB3/2145).

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Formalin-fixed, paraffin-embedded human Kidney stained with CD61 Mouse Monoclonal Antibody (ITGB3/2145).

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SDS-PAGE Analysis Purified CD61 Mouse Monoclonal Antibody (ITGB3/2145).

Product Details

Synonyms

BDPLT2; GP3A; GPIIIa; GT; HPA 1; HPA 4; Integrin beta-3; ITGB3; NAIT; Platelet fibrinogen receptor beta subunit; Platelet glycoprotein IIIa; PTP

Positive Control

U937, KG1a, HEL cells. Spleen.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human ITGB3 protein fragment (aa 385-490) (exact sequence is proprietary)

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

105kDa & 90kDa

Specificity & Comments

Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain). It associates with the IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61).The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Gatter KC, Cordell JL, Turley H, Heryet A, Kieffer N, Anstee DJ, et al. The immunohistological detection of platelets, megakaryocytes and thrombi in routinely processed specimens. Histopathology 1988; 13:257 -67.

Bioinformatics

  •  Entrez Gene ID: 3690
  •  Gene Symbol: ITGB3
  •  SwissProt: P05106
  •  Chromosome Location: 17q21.32
  •  Unigene: 218040
NBT02145