Home >> Antibodies >> CD40 / TNFRSF5 / CD40L-Receptor

CD40 / TNFRSF5 / CD40L-Receptor

Recombinant Rabbit Monoclonal Antibody [Clone C40/4826R]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded human tonsil stained with CD40 Recombinant Rabbit Monoclonal Antibody (C40/4826R).

Formalin-fixed, paraffin-embedded human tonsil stained with CD40 Recombinant Rabbit Monoclonal Antibody (C40/4826R).

SDS-PAGE Analysis Purified CD40 Recombinant Rabbit Monoclonal Antibody (C40/4826R). Confirmation of Integrity and Purity of Antibody.

Formalin-fixed, paraffin-embedded human tonsil stained with CD40 Recombinant Rabbit Monoclonal Antibody (C40/4826R).

SDS-PAGE Analysis Purified CD40 Recombinant Rabbit Monoclonal Antibody (C40/4826R). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

B-cell surface antigen CD40; Bp50; CD40; CD40L receptor; GP39; HIGM1; IGM; IMD3; p50; TBAM; TNF receptor superfamily member 5; TNFRSF5; TRAP

Positive Control

U2OS or L-428 cells. Human tonsil, spleen or thymus.

Known Applications & Suggested Dilutions

ELISA, IHC-P More Details

ELISA (For coating, order antibody without BSA)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human CD40 protein (around aa 29-107) (exact sequence is proprietary)

Cellular Localization

Cell Surface. Secreted.

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

43kDa

Specificity & Comments

CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes, follicular dendritic cells, bone marrow-derived dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zones of secondary lymphoid organs.