CD40, Mouse [FGK45.5]

Clear

Summary

Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. FGK4.5 can be used for blocking of CD40/CD154 interaction and forin vitroandin vivoactivation of CD40 expressing APCs. This MAb is shown to indirectly activate natural killer (NK) cells, producing significant antitumor and anti-metastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.

Product Properties & Targets

Host
Rat
Species Reactivity
Isotype
Cellular Localization
Gene Name
CD40
Mol. Weight of Antigen
48kDa
Immunogen
Purified recombinant Mouse CD40 fusion protein

Database Links

Entrez Gene ID
Unigene
SwissProt

Additional Information

Clone
FGK45.5
Chromosome Location
2 H3; 2 85.38 cM (Mouse)

Known Applications & Suggested Dilutions

  • Functional Studies (Order Antibody without BSA & Azide)
  • Flow Cytometry (0.5-1ug/million cells in 0.1ml)
  • Immunofluorescence (1-2ug/ml)
  • Optimal dilution for a specific application should be determined.

Key References

  • Agonistic Anti-CD40 Antibody Profoundly Suppresses the Immune Response to Infection with Lymphocytic Choriomeningitis Virus C. Bartholdy, et al. J. Immunol. 178 1662 (2007)

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

Recombinant mouse monoclonal antibodies and recombinant rabbit monoclonals to support your research

Shop Primary Antibodies