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Home >> Antibodies >> CD1b (T-Cell Surface Glycoprotein)

CD1b (T-Cell Surface Glycoprotein)

Mouse Monoclonal Antibody [Clone 100-1A5]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified CD1b Mouse Monoclonal Antibody (100-1A5). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

A1 domain; CD1B; Cortical thymocyte antigen CD1B; hTa1 thymocyte antigen; Ly38; T cell surface glycoprotein CD1b; T6/Leu6

Positive Control

MOLT4 cells. Human thymus.

Known Applications & Suggested Dilutions

Flow Cyt, IF, Func.         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Functional Studies (Order Ab without BSA & Azide)
Optimal dilution for a specific application should be determined.

Immunogen

Stimulated human leukocytes

Cellular Localization

Cell surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgM, kappa

Mol. Weight of Antigen

44kDa

Specificity & Comments

The Mouse monoclonal antibody recognizes CD1b, a 44kDa type I glycoprotein associated with beta2-microglobulin (Workshop IV; Code T015). It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells. The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Battistini L, et al. CD1b is expressed in multiple sclerosis lesions. J Neuroimmunol 1996, 67(2):145-151.
  2. Knapp W. et al. (eds) Leukocyte Typing IV, p251-263, Oxford University Press, Oxford, 1989.
  3. Khalili-Shirazi A, et al. The distribution of CD1 molecules in inflammatory neuropathy. J Neurol Sci 1998,158(2):154-163.
  4. Maher JK and Kronenberg M. The role of CD1 molecules in immune responses to infection. Curr Opin Immunol 1997, 9(4):456-46

Bioinformatics

  •  Entrez Gene ID: 910
  •  Gene Symbol: CD1B
  •  SwissProt: P29016
  •  Chromosome Location: 1q23.1
  •  Unigene: 1310
NBT01044