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Arginase 1 (Hepatocellular Carcinoma Marker)

Mouse Monoclonal Antibody [Clone ARG1/1125+ ARG1/1126]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Formalin-paraffin human Hepatocellular Carcinoma stained with ARG1 Mouse Monoclonal Antibody (ARG1/1125 + ARG1/1126).

Formalin-paraffin human Hepatocellular Carcinoma stained with ARG1 Mouse Monoclonal Antibody (ARG1/1125 + ARG1/1126).

Product Details

Synonyms

Arginase 1; ARG1; liver-type arginase; type I arginase

Positive Control

293T cells. Hepatocellular Carcinoma (HCC).

Known Applications & Suggested Dilutions

Immunohistology More Details

Immunohistology (Formalin-fixed) (2-4ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human ARG1 protein fragment (around aa11-97) (exact sequence is proprietary)

Cellular Localization

Cytoplasmic

Species Reactivity

Human. Others not known.

Host / Ig Isotype

Mouse / IgG3, kappa + Mouse / IgG3, kappa

Mol. Weight of Antigen

35-38kDa

Specificity & Comments

Recognizes a protein of 35-38kDa, which is identified as Arginase 1 (ARG1). Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of arginine to generate ornithine and urea. Arginase I and II are isoenzymes, which differ in subcellular localization, regulation, and possibly function. Arginase I is a cytosolic enzyme, which is expressed mainly in the liver as part of the urea cycle, whereas arginase II is a mitochondrial protein found in a variety of tissues. Antibody to ARG-1 labels hepatocytes in normal tissues and granulocytes in peripheral blood. ARG-1 is a sensitive and specific marker for identification of hepatocellular carcinoma.