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Recombinant TAG-72 / CA72.4 (Tumor-Associated Glycoprotein) Antibody [rB72.3]

In Stock
Catalog Number Formulation Size Price
182875-MSM8-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
182875-MSM8-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
182875-MSM8-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Recognizes an oncofetal antigen of 220kDa, identified as a tumor-associated glycoprotein (TAG-72) with properties of a mucin. This MAb defines the mucin-carried sialylated-Tn epitope. TAG-72 is usually expressed by adenocarcinomas, but is negative in mesotheliomas. Studies have reported that this antibody has 80% sensitivity and 93% specificity for pulmonary adenocarcinoma. Therefore, TAG-72 is a useful marker to distinguish between mesothelioma and adenocarcinoma. However, false positive reactions can occur so results must be interpreted with the utmost caution. This antibody may be useful in the differentiation of non-small cell carcinomas from small cell carcinomas of the lung. The combined use of anti-TAG-72 and anti-GCDFP-15 is valuable in the diagnosis of apocrine carcinoma.

Product Properties & Targets

Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
N/A
Gene Name
N/A
Positive Control
Breast or lung carcinoma., Jurkat cells
Immunogen
Membrane-enriched fraction of a human breast carcinoma liver metastasis
Alternate Names
N/A, N/A, CA72.4, Tumor associated glycoprotein 72

Database Links

Entrez Gene ID
SwissProt
N/A

Additional Information

Clone
rB72.3
Mol. Weight of Antigen
220kDa

Functions

  • N/A

Key References

  • Lottich SC et. al. Breast Cancer Research and Treatment, 1985, 6(1):49-56.
  • Thor A et. al. Cancer Research, 1986, 46(6):3118-24.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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