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Formalin-fixed, paraffin-embedded human tonsil stained with Parvalbumin Recombinant Rabbit Monoclonal Antibody (PVALB/12794R). Inset: PBS instead of primary antibody; secondary only negative control.
Analysis of Protein Array containing more than 19,000 full-length human proteins using Parvalbumin Recombinant Rabbit Monoclonal Antibody (PVALB/12794R). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Parvalbumin alpha is a low molecular weight calcium-bound albumin (usually 9-11 kDa), structurally related to calmodulin and troponin C, and is a stable protein involved in calcium signaling. Parvalbumin is involved in physiological processes such as cell cycle regulation, second messenger production, muscle contraction, microtubule organization and light conduction. Parvalbumin alpha is found in rapidly contracting muscles, where its levels are highest, as well as in the brain and some endocrine tissues. In normal kidneys, parvoprotein has been shown to be confined to distal tubule cells and collecting tubule cells (intercellular cells).
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