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Recombinant Parvalbumin / PVALB Antibody [r2E11]

In Stock
Catalog Number Formulation Size Price
5816-MSM42-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$249.00
5816-MSM42-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$539.00
5816-MSM42-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$539.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Parvalbumin Alpha Antibody in SDS-PAGE

Parvalbumin Alpha Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified Parvalbumin Alpha Recombinant Mouse Monoclonal Antibody (r2E11). Confirmation of Purity and Integrity of Antibody.

Parvalbumin Antibody in Western Blot (WB)

Parvalbumin Antibody in Western Blot (WB)

Western blot analysis of human kidney tissue lysate using Parvalbumin Recombinant Mouse Monoclonal Antibody (r2E11).

Parvalbumin Antibody in Western Blot (WB)

Parvalbumin Antibody in Western Blot (WB)

Western blot analysis of human heart tissue lysate using Parvalbumin Recombinant Mouse Monoclonal Antibody (r2E11).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

Alpha and beta parvalbumins are low molecular weight, water-soluble, calcium binding proteins. Alpha and beta parvalbumins are expressed in different human tissues, with the alpha form detected strongly in extracts of human cerebellum and weakly in kidney, but not in skeletal muscle, thymus, lung, placenta, heart, liver and diaphragm. The beta form of parvalbumin has been detected only in preterm placenta. Within the cerebellum, alpha parvalbumin is highly localized to Purkinje, basket, stellate and Golgi cells.

Reacts with human parvalbumin alpha. Does NOT detect beta parvalbumin in pre-term placenta.

Product Properties & Targets

Antibody Type
Mouse Monoclonals, Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Research Areas
Neuroscience
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cell junction, Cytoplasm, Nucleus
Gene Name
PVALB
Positive Control
Human brain, heart or kidney.
Immunogen
Prokaryotic recombinant fusion protein corresponding to the majority of the parvalbumin alpha molecule
Alternate Names
Parvalbumin alpha, PVALB; Parvalbumin alpha

Database Links

Entrez Gene ID
5816
SwissProt
P20472

Additional Information

Clone
r2E11
Chromosome Location
22q12.3
Mol. Weight of Antigen
12kDa

Related Antibodies

View All PVALB Antibodies

Functions

  • In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

Key References

  • Tong, Y., et al. 2005. Suppression of expression of muscle-associated proteins by PPARα in brown adipose tissue. Biochem. Biophys. Res. Commun. 336: 76-83.
  • Young A N, Amin M B, Moreno C S, et al American Journal of Pathology. 158 (5): 1639–1651 (2001).
  • Brady D R and Mufson E J. Neuroscience. 80 (4): 1113–1125 (1997).
  • Vig P J S, Fratkin J D, Desaiah D, et al Neurology. 47: 249–253 (1996).
  • Sorvari H, Soininen H, Paljärvi L, et al The Journal of Comparative Neurology. 360: 185–212 (1995).
  • Föhr U G, Weber B R, Müntener M, et al European Journal of Biochemistry. 215: 719–727 (1993).

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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