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Mesothelial Cells (Mesothelioma Marker) Antibody [HBME-1]

In Stock
Catalog Number Formulation Size Price
MSM1-9708-CS0
Culture Supernatant
0.1ml
$229.00
MSM1-9708-CS1
Culture Supernatant
0.5ml
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunofluorescence (IF)
1:100-1:200
Immunohistochemistry (IHC)
1:100-1:200
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Mesothelioma, a form of cancer caused by previous exposure to asbestos, causes malignant cells to flourish within the mesothelium, a protective lining that covers most of the internal organs of the body. Mesothelioma is most commonly found in the pleura, but it may also occur in the pericardium or peritoneum. When asbestos fibers deposit in the parenchyma of the lung, they penetrate the visceral pleura, from where the fiber can then be carried to the pleural surface, leading to the development of malignant mesothelial plaques. Shortness of breath, cough and pain in the chest due to an accumulation of fluid in the pleural space are often symptoms of Mesothelioma, but may not appear until 20 to 50 years after an initial exposure to asbestos. Because Mesothelioma is a highly aggressive tumor that is generally deadly,
treatments using conventional therapies are not successful, limiting patients to a median survival time of 6-12 months after presentation. Markers for Mesothelioma are useful in the study of function and behavior of this tissue.

This antibody reacts with an unknown antigen on microvilli of mesothelioma cells. It stains normal mesothelial cells as well as epithelial mesotheliomas in a thick membrane pattern due to abundant lung microvilli on the surface of these cells.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgM / Kappa
Cellular Localization
Cell membrane
Gene Name
N/A
Positive Control
Mesothelial cells or mesothelioma.
Immunogen
BALB/C mice were injected with suspension of human mesothelioma cells from patients with malignant epithelial mesothelioma.
Alternate Names
N/A, N/A, Not Known

Database Links

Entrez Gene ID
SwissProt
N/A

Additional Information

Clone
HBME-1
Chromosome Location
Not Known
Mol. Weight of Antigen
Not Known

Functions

  • N/A

Key References

  • Zhao, J., Lin, D.L., Zhai, L.H. and Wang, J.G. 2014. Evaluation of ultrasound-processed rapid cell blocks in the cytopathologic diagnosis of cavity fluids. Acta Cytol. 58: 182-191.
  • Zucali, P.A. and Giaccone, G. 2006. Biology and management of malignant pleural mesothelioma. Eur. J. Cancer 42: 2706-2714.

Storage & Stability

Store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

Tissue culture supernatant with 0.05% Azide. Contact us if you require it in a different format.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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