SDS-PAGE Analysis Purified HHV8 Recombinant Rabbit Monoclonal Antibody (HHV8/3633R). Confirmation of Purity and Integrity of Antibody.

SDS-PAGE Analysis Purified HHV8 Recombinant Rabbit Monoclonal Antibody (HHV8/3633R). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human Kaposi's sarcoma stained with HHV8 Recombinant Rabbit Monoclonal Antibody (HHV8/3633R).

Formalin-fixed, paraffin-embedded human Kaposi's sarcoma stained with HHV8 Recombinant Rabbit Monoclonal Antibody (HHV8/3633R).

Human Herpes Virus 8 (HHV8) [HHV8/3633R]

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Summary

HHV8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene orf 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenic activity. HHV8 is associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. HHV8 is the likely etiological agent of Kaposi's sarcoma.

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Product Properties & Targets

Host
Rabbit
Species Reactivity
Species Independent
Isotype
IgG
Cellular Localization
N/A
Gene Name
N/A
Mol. Weight of Antigen
Not Known
Immunogen
Recombinant protein corresponding to the latent nuclear antigen 1 molecule of HHV8

Database Links

Entrez Gene ID
Not Applicable
Unigene
Not Applicable
SwissProt
N/A

Additional Information

Clone
HHV8/3633R
Human Gene Symbol
Not Applicable
Chromosome Location
Not Applicable

Known Applications & Suggested Dilutions

  • ELISA (For coating use Ab at 1-5ug/ml, order Ab without BSA)
  • Immunofluorescence (1-2ug/ml)
  • ,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Key References

  • Ablashi et al. Clinc Microbiol Reviews 15: 439, 2002
  • Dupin et al. Proc. Natl. Acad. Sci. USA 96: 4546, 1999.
  • Kellam et al. J Virol 73: 5149, 1999.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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