HPV-16 E6 + HPV-18 E6 (Human Papilloma Virus 16/18) [HPV16/1295 + HPV18/1297]

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Summary

Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis has shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.

Product Properties & Targets

Host
Isotype
Cellular Localization
N/A
Gene Name
N/A
Mol. Weight of Antigen
16/17kDa
Immunogen
HPV18 E6-β-galactosidase fusion protein

Database Links

Entrez Gene ID
Unigene
SwissProt
N/A

Additional Information

Clone
HPV16/1295 + HPV18/1297
Human Gene Symbol
Not Applicable
Chromosome Location
Not Applicable

Known Applications & Suggested Dilutions

  • ELISA (For coating, order antibody without BSA)
  • Optimal dilution for a specific application should be determined.

Key References

  • McLean CS, J Clin Pathol, 1990; 43:488-492.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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