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Recombinant Cytokeratin 19 (Pancreatic Stem Cell Marker) Antibody [KRT19/8091R]

In Stock
Catalog Number Formulation Size Price
3880-RBM20-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
3880-RBM20-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
3880-RBM20-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Recognizes a protein of 40kDa, identified as cytokeratin-19 (CK19), which is expressed in sweat gland, mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type, although 50%-60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer.

Product Properties & Targets

Host
Rabbit
Applications
Species Reactivity
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Cytoplasm
Gene Name
Positive Control
MCF-7 or HeLa cells. Breast cancer tissues.
Immunogen
Recombinant full-length human KRT19 protein.
Alternate Names
Keratin, type I cytoskeletal 19, Cytokeratin-19, Keratin-19, k19; k1cs; Keratin 19 Keratin Type i 40kD; KRT19

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
KRT19/8091R
Chromosome Location
17q21.2
Mol. Weight of Antigen
40kDa

Functions

  • Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Key References

  • Van Eyken, P., et al. 1991. Immunocytochemistry of cytokeratins in primary human liver tumors. APMIS Suppl. 23: 77-85.
  • van der Velden, L.A., et al. 1993. Cytokeratin expression in normal and (pre)malignant head and neck epithelia: an overview. Head Neck 15: 133-146.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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