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Recombinant Calbindin 1 (CALB1) Antibody [rCALB1/8499]

In Stock
Catalog Number Formulation Size Price
793-MSM7-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
793-MSM7-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
793-MSM7-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

The family of EF-hand type Ca2+-binding proteins includes Calbindin D28K, Calbindin D9K, S-100 Î � and Î �, Calgranulin A (also designated MRP8), Calgranulin B (also designated MRP14), Calgranulin C and the Parvalbumin family members, including Parvalbumin Î � and Parvalbumin Î � (also designated oncomodulin). Calbindin D28K, also known as calbindin, CALB1, D-28K or vitamin D-dependent calcium-binding protein, is a 261-amino acid protein with 6 EF-hand domains, 4 of which are active calcium-binding domains. Expressed in brain, ovary, uterus, testis, pancreas, liver, kidney and intestine, Calbindin D28K acts as a calcium-buffering agent and alters the activity of the plasma membrane ATPase. In neuronal cells, Calbindin D28K modulates calcium channel activity, calcium transients and intrinsic neuronal firing activity. Also, Calbindin D28K has been implicated to play a role in apoptosis and microtubule function.

Product Properties & Targets

Host
Mouse
Applications
Species Reactivity
Research Areas
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Nucleus. Cytoplasm.
Gene Name
Positive Control
293T or HepG2 cells. Human prostate|kidney or liver.|lung|pancreas
Immunogen
Recombinant fragment (around aa 7-96) of human CALB1 protein (exact sequence is proprietary)
Alternate Names
Calbindin, Calbindin D28, D-28K, Vitamin D-dependent calcium-binding protein, avian-type, avian-type; CAB27; CALB 1; CALB; CALB1; CALB1_HUMAN; Calbindin 1 28kDa; Calbindin; Calbindin D28; D 28K; D-28K; D28K; OTTHUMP00000166027; OTTHUMP00000225441; RTVL H protein; Vitamin D dependent calcium binding protein; Vitamin D dependent calcium binding protein avian type; Vitamin D-dependent calcium-binding protein

Database Links

Entrez Gene ID
793
SwissProt

Additional Information

Clone
rCALB1/8499
Chromosome Location
8q21.3
Mol. Weight of Antigen
52kDa

Functions

  • Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3', 5'-cyclic nucleotide phosphodiesterase.

Key References

  • Parmentier, M., et al. 1989. Genomics 4: 309-319.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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