Formalin-fixed, paraffin-embedded human Colon stained with Aurora B Rabbit Recombinant Monoclonal Antibody (AURKB/3121R).
SDS-PAGE Analysis Purified Aurora B Rabbit Recombinant Monoclonal (AURKB/3121R). Confirmation of Purity and Integrity of Antibody.
Recognizes a protein of 39kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.
