S100A1 Antibodies

S100A1 is a calcium-binding protein belonging to the S100 protein family. It is encoded by the S100A1 gene on chromosome 1q21 in humans. The S100A1 protein consists of 94 amino acids with a molecular weight of approximately 10.4 kDa. Post-translational modifications of S100A1 include phosphorylation, nitrosylation, and acetylation, which can influence its activity and interaction with other proteins.

S100A1 is an intracellular protein that plays a crucial role in calcium signaling and homeostasis, particularly in cardiac and skeletal muscle cells, where it regulates contractile function by modulating the activity of ion channels and enzymes involved in calcium handling. S100A1 expression has also been observed in neurons, possibly contributing to synaptic plasticity and neuronal function. Additionally, S100A1 interacts with various proteins involved in calcium signaling, including the ryanodine receptor and sarco/endoplasmic reticulum calcium ATPase (SERCA), modulating their activity and contributing to muscle contraction and relaxation. The expression of S100A1 is tightly regulated in response to various physiological and pathological stimuli, including changes in calcium levels, hormonal signals, and cellular stress. Transcriptional and post-transcriptional mechanisms control S100A1 expression in different cell types and tissues.

Dysregulation of S100A1 expression or activity has been implicated in various cardiovascular diseases, including heart failure, ischemic heart disease, and cardiomyopathies. Reduced levels of S100A1 have been associated with impaired contractile function, increased susceptibility to arrhythmias, and poor prognosis in heart failure patients. Therefore, S100A1 expression analysis may offer valuable diagnostic and prognostic information for treating heart failure and other cardiovascular disorders. 

NeoBiotechnologies offers a variety of antibodies against S100A1 that have been validated for immunofluorescence and immunohistochemistry, as well as a HuProt validated option. Additionally, we hold exclusive rights to S100A1 antibodies available for licensing or collaboration https://www.neobiotechnologies.com/shop/?s=S100A1].

Synonyms

Protein S100-A1, S100|S100-alpha|S100A

Research Areas

Apoptosis, Autophagy, Breast Cancer, Cancer, Cardiovascular, Cell Biology, Cellular Markers and Tags, Developmental Biology, Endocrine, Epigenetics, Gastrointestinal Tract, Hypoxia, Immuno Oncology, Immunology, Kidney, Lymphatic, Metabolism, Microbiology, Muscle, Neuroscience, Pancreatic Cancer, Prostate Cancer, Skin, Stem Cell, AKT Signaling, Angiogenesis, Articular Cartilage Extracellular Matrix, B Cell Markers, Basal Cell Marker, BBB VCAM-1 Signaling, Bladder Cancer, Cardiac Stem Cells, Colon Cancer, Colorectal Cancer, Complement System, CTLA-4 blockade immunotherapy, Cytokine Signaling, Defective Intrinsic Apoptosis, Dendritic Cell Marker, Digestion, Endothelial Cell Marker, Hematopoietic Stem Cells, Immune checkpoint, Infectious Disease, Lipid Metabolism, Lung Cancer, MAPK Signaling, Mast Cell Marker, Melanoma, Mesenchymal Stem Cell Differentiation, Mitochondria Marker, Neural Stem Cells, Neuroinflammation, Nuclear Marker, Oncology, Ovarian Cancer, PD-1 blockade immunotherapy, Signal Transduction, Stem Cell Differentiation, Transcription Factors