Fibronectin (Fn1) is a large glycoprotein with a molecular weight that varies depending on its isoform but is generally around 220-250 kDa. This protein is widely expressed in various tissues, is a major component of the extracellular matrix (ECM), and is produced by fibroblasts, endothelial cells, and other cell types.
Fibronectin serves as a key structural and adhesive molecule in the ECM, plays a crucial role in cell adhesion, migration, and tissue repair, and also participates in processes such as embryonic development and blood clotting.
Abnormalities in fibronectin expression or function are associated with various diseases and conditions, including fibrosis, cancer progression, and certain cardiovascular diseases. Altered fibronectin levels may be observed in conditions such as arthritis and tissue injuries.
Antibodies against fibronectin are used in research to study its expression and localization in tissues and cells. Immunohistochemistry and immunofluorescence techniques employing anti-fibronectin antibodies help researchers understand its role in various physiological and pathological processes. In the clinical setting, fibronectin is explored as a potential biomarker in certain diseases, including cancer. Measuring fibronectin levels may provide information about the severity of fibrotic diseases. Furthermore, targeting fibronectin or its interactions may be considered in conditions with excessive fibrosis or abnormal tissue remodeling.
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