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Cyclin-Dependent Kinase 4 (CDK4) has a molecular weight of approximately 34 kDa. It is expressed in various tissues, but its levels fluctuate throughout the cell cycle, peaking during the G1 phase, making it a key regulator of the cell cycle progression. Since aberrant activation or overexpression can contribute to uncontrolled cell division and tumor formation, it is often implicated in cancer.
Antibodies against CDK4 are used in research to study its expression levels in cells and tissues. Immunohistochemistry and western blotting are common techniques employing these antibodies to investigate its presence and regulation in normal and pathological conditions. In a diagnostic context, assessing Cyclin-Dependent Kinase 4 expression levels in tumors may provide information about the aggressiveness of certain cancers and help guide treatment decisions.
Cyclin-dependent kinase 4, Cell division protein kinase 4, PSK-J3, CDK4 protein; CDK4_HUMAN; Cell division protein kinase 4; CMM3; Crk3; Cyclin dependent kinase 4; Melanoma cutaneous malignant 3; MGC14458; p34 cdk4; PSK-J3
Breast Cancer, Cardiovascular, Developmental Biology, Bladder Cancer, Infectious Disease, Lung Cancer, Signal Transduction, Transcription Factors
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