Formalin-fixed, paraffin-embedded human Urothelial Carcinoma stained with Uroplakin 1A Mouse Monoclonal Antibody (UPK1A/2922).
Formalin-fixed, paraffin-embedded human Bladder stained with Uroplakin 1A Mouse Monoclonal Antibody (UPK1A/2922).
SDS-PAGE Analysis Purified Uroplakin 1A Mouse Monoclonal Antibody (UPK1A/2922). Confirmation of Purity and Integrity of Antibody.
Analysis of Protein Array containing more than 19,000 full-length human proteins using Uroplakin 1A Mouse Monoclonal Antibody (UPK1A/2922)
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression.