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Home >> Antibodies >> Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme)

Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme)

Mouse Monoclonal Antibody [Clone SOD1/2089]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human Placenta stained with Superoxide Dismutase 1 Mouse Monoclonal Antibody (SOD1/2089).

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SDS-PAGE Analysis Purified Superoxide Dismutase 1 Mouse Monoclonal Antibody (SOD1/2089). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Superoxide Dismutase 1 Mouse Monoclonal Antibody (SOD1/2089).

Product Details

Synonyms

Amyotrophic lateral sclerosis 1 (ALS1); Cu/Zn SOD; Cu/Zn Superoxide Dismutase; Epididymis Secretory Protein Li 44; Indophenoloxidase A (IPOA); Superoxide Dismutase [Cu-Zn]; Superoxide Dismutase 1 (SOD1)

Positive Control

HeLa or Jurkat Cells. Breast or Ovarian carcinoma

Known Applications & Suggested Dilutions

Immunohistology         More Details

Immunohistology (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human SOD1 protein

Cellular Localization

Nucleoplasm, Cytoplasm, Plasma membrane.

Species Reactivity

Human. Others-not known.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

16kDa

Specificity & Comments

Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Levanon, D., et al. 1985. Architecture and anatomy of the chromosomal locus in human chromosome 21 encoding the Cu-Zn superoxide dismutase. EMBO J. 4: 77-84.

Bioinformatics

  •  Entrez Gene ID: 6647
  •  Gene Symbol: SOD1
  •  SwissProt: P00441
  •  Chromosome Location: 21q22.11
  •  Unigene: 443914