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Home >> Antibodies >> SOX9 / SRY-box 9

SOX9 / SRY-box 9

Mouse Monoclonal Antibody [Clone PCRP-SOX9-1A2]

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Catalog No Formulation Size Price (USD)  
6662-MSM2-P0 Purified Ab with BSA and Azide at 200ug/ml 20 ug 199.00
6662-MSM2-P1 Purified Ab with BSA and Azide at 200ug/ml 100 ug 429.00
6662-MSM2-P1ABX Purified Ab WITHOUT BSA and Azide at 1.0mg/ml 100 ug 429.00
Human Entrez Gene ID 6662
Human SwissProt P48436
Human Unigene 647409
Human Gene Symbol SOX9
Human Chromosome Location 17q24.3
Synonyms Campomelic Dysplasia Autosomal Sex Reversal (CMD1); SRA1; SRXX2; SRY (sex determining region Y) box 9; SRY related HMG box gene 9; Transcription factor SOX9
Immunogen Recombinant human full-length SOX9 protein
Host / Ig Isotype Mouse / IgG2b
Mol. Weight of Antigen 65kDa
Cellular Localization Nuclear
Species Reactivity Human. Others-not tested.

Specificity & Comments

The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Sox genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. SOX9 plays an important role in the normal skeletal development. It may regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.

Known Applications & Suggested Dilutions

Immunohistology (Formalin-fixed) (2-4ug/ml for 30 min at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Positive Control

HepG2 Cells. Pancreas

Supplied As

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Storage and Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. ,Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

Key References

  1. Zhu, H., et al. 2013. Upregulation of SOX9 in osteosarcoma and its association with tumor progression and patients prognosis. Diagn.Pathol. 8:183
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