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Home >> Antibodies >> SOX2 (Embryonic Stem CellMarker)

SOX2 (Embryonic Stem CellMarker)

Mouse Monoclonal Antibody [Clone SOX2/1791]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Cervical Carcinoma stained with SOX2 Mouse Monoclonal Antibody (SOX2/1791).

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Western Blot of Recombinant SOX2 protein fragment and NCCIT cell lysate using SOX2 Mouse Monoclonal Antibody (SOX2/1791).

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Formalin-fixed, paraffin-embedded human Lung Carcinoma stained with SOX2 Mouse Monoclonal Antibody (SOX2/1791).

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Formalin-fixed, paraffin-embedded MouseStomach stained with SOX2 Mouse Monoclonal Antibody (SOX2/1791).

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Formalin-fixed, paraffin-embedded MouseBrain stained with SOX2 Mouse Monoclonal Antibody (SOX2/1791).

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Formalin-fixed, paraffin-embedded MouseIntestine stained with SOX2 Mouse Monoclonal Antibody (SOX2/1791).

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SDS-PAGE Analysis Purified SOX2 Mouse Monoclonal Antibody (SOX2/1791). Confirmation of Integrity and Purity of Antibody.

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Western Blot Analysis of human A549 cell lysate using SOX2 Mouse Monoclonal Antibody (SOX2/1791).

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Analysis of Protein Array containing more than 19,000 full-length human proteins using SOX2 Mouse Monoclonal Antibody (SOX2/1791)

Product Details

Synonyms

ANOP3; Delta EF2a;MCOPS3 (Microphthalmia Syndromic type 3);SOX-2; SRY (sex determining region Y) box 2; SRY related HMG box 2; Transcription factor SOX-2; ysb

Positive Control

A549, NCCIT cells. Lung or Cervicalcarcinoma.

Known Applications & Suggested Dilutions

ELISA, Western Blot, IHC-P         More Details

ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA)
Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (within aa176-305) of human SOX2 protein (exact sequence is proprietary)

Cellular Localization

Nuclear

Species Reactivity

Human. Mouse.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

34kDa

Specificity & Comments

SOX2 is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach. SOX2 is necessary for regulating multiple transcription factors that affect Oct 3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct 3/4 expression. Reportedly, SOX2 is associated with aggressive phenotypes of breast, head and neck, gastric, colorectal, bladder, and small cell lung cancers. However, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and has been shown to be an independent favorable prognostic marker.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Laudet, V., Stehelin, D. and Clevers, H. 1993. Nucleic Acids Res. 21: 2493-2501

Bioinformatics

  •  Entrez Gene ID: 6657
  •  Gene Symbol: SOX2
  •  SwissProt: P48431
  •  Chromosome Location: 3q26.33
  •  Unigene: 518438
NBT01791