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Home >> Antibodies >> SOX2 (Embryonic Stem Cell Marker)

SOX2 (Embryonic Stem Cell Marker)

Mouse Monoclonal Antibody [Clone SOX2/1791]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded Human Cervical Carcinoma stained with SOX2 Mouse Monoclonal Antibody (SOX2/1791).

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Western Blot of Recombinant SOX2 protein fragment and NCCIT cell lysate using SOX2 Mouse Monoclonal Antibody (SOX2/1791).

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Formalin-fixed, paraffin-embedded Human Lung Carcinoma stained with SOX2 Mouse Monoclonal Antibody (SOX2/1791).

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Formalin-fixed, paraffin-embedded Mouse Stomach stained with SOX2 Mouse Monoclonal Antibody (SOX2/1791).

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Formalin-fixed, paraffin-embedded Mouse Brain stained with SOX2 Mouse Monoclonal Antibody (SOX2/1791).

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Formalin-fixed, paraffin-embedded Mouse Intestine stained with SOX2 Mouse Monoclonal Antibody (SOX2/1791).

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SDS-PAGE Analysis Purified SOX2 Mouse Monoclonal Antibody (SOX2/1791). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using SOX2 Mouse Monoclonal Antibody (SOX2/1791)

Product Details

Synonyms

ANOP3; Delta EF2a; MCOPS3 (Microphthalmia Syndromic type 3); SOX-2; SRY (sex determining region Y) box 2; SRY related HMG box 2; Transcription factor SOX-2; ysb

Positive Control

MCF-7 cells. Lung or Cervical carcinoma

Known Applications & Suggested Dilutions

ELISA, WB, IHC-P         More Details

ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA)
Western Blotting (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (within aa176-305) of human SOX2 protein (exact sequence is proprietary)

Cellular Localization

Nuclear

Species Reactivity

Human. Mouse. Others not known.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

34kDa

Specificity & Comments

SOX2 is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach. SOX2 is necessary for regulating multiple transcription factors that affect Oct 3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct 3/4 expression. Reportedly, SOX2 is associated with aggressive phenotypes of breast, head and neck, gastric, colorectal, bladder, and small cell lung cancers. However, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and has been shown to be an independent favorable prognostic marker.

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200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Laudet, V., Stehelin, D. and Clevers, H. 1993. Nucleic Acids Res. 21: 2493-2501

Bioinformatics

  •  Entrez Gene ID: 6657
  •  Gene Symbol: SOX2
  •  SwissProt: P48431
  •  Chromosome Location: 3q26.33
  •  Unigene: 518438
DOC#01791