SOX2 Antibodies

SOX2 (SRY [sex-determining region Y]-box 2) has a molecular weight of approximately 34 kDa. This transcription factor is expressed in various tissues during embryonic development and is crucial for the development of the nervous system, eyes, and other organs. In adults, its expression is found in specific tissues, including neural stem cells and other stem cell populations.

Mutations or dysregulation of SOX2 are associated with developmental disorders and certain cancers, including lung cancer, esophageal cancer, and glioblastoma.

Antibodies against SOX2 are used in research to study the expression and localization of SRY-box 2 in tissues and cells. In cancer research, these antibodies can help identify the presence and abundance of SRY-box 2 in tumor samples, aiding in classification and prognosis. Its expression can have diagnostic implications in certain cancers, where it may serve as a biomarker potentially influencing treatment decisions.

Synonyms

Transcription factor SOX-2, ANOP3|MCOPS3

Research Areas

Apoptosis, Autophagy, Breast Cancer, Cancer, Cardiovascular, Cell Biology, Cellular Markers and Tags, Developmental Biology, Endocrine, Epigenetics, Gastrointestinal Tract, Hypoxia, Immuno Oncology, Immunology, Kidney, Lymphatic, Metabolism, Microbiology, Muscle, Neuroscience, Pancreatic Cancer, Prostate Cancer, Skin, Stem Cell, AKT Signaling, Angiogenesis, Articular Cartilage Extracellular Matrix, B Cell Markers, Basal Cell Marker, BBB VCAM-1 Signaling, Bladder Cancer, Cardiac Stem Cells, Colon Cancer, Colorectal Cancer, Complement System, CTLA-4 blockade immunotherapy, Cytokine Signaling, Defective Intrinsic Apoptosis, Dendritic Cell Marker, Digestion, Endothelial Cell Marker, Hematopoietic Stem Cells, Immune checkpoint, Infectious Disease, Lipid Metabolism, Lung Cancer, MAPK Signaling, Mast Cell Marker, Melanoma, Mesenchymal Stem Cell Differentiation, Mitochondria Marker, Neural Stem Cells, Neuroinflammation, Nuclear Marker, Oncology, Ovarian Cancer, PD-1 blockade immunotherapy, Signal Transduction, Stem Cell Differentiation, Transcription Factors