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Recombinant SOX2 (Embryonic Stem Cell Marker) Antibody [SOX2/4267R]

Additional information

Catalog Number: 6657-RBM7
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
6657-RBM7-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
6657-RBM7-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
6657-RBM7-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant SOX2 (Embryonic Stem Cell Marker) Antibody

IHC analysis of formalin-fixed, paraffin-embedded human cervix. Strong nuclear staining using SOX2/4267R at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Recombinant SOX2 (Embryonic Stem Cell Marker) Antibody - Image 2

IHC analysis of formalin-fixed, paraffin-embedded human tonsil. Strong nuclear staining using SOX2/4267R at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

SOX2 Antibody in SDS-PAGE

SOX2 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified Transcription factor SOX-2 Recombinant Rabbit Monoclonal Antibody (SOX2/4267R). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Rabbit Monoclonals, Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
SOX2/4267R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Cytoplasm, Nucleus, Nucleus speckle
Gene Name
SOX2
Positive Control
MCF-7 cells. Human lung or cervical carcinoma.
Immunogen
Recombinant fragment of human SOX2 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity).
Key References
  • Laudet, V., et al. 1993. Ancestry and diversity of the HMG box superfamily. Nucleic Acids Res. 21: 2493-2501.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
6657
SwissProt
P48431
Chromosome Location
3q26.33
Mol. Weight of Antigen
34kDa
Alternate Names
Transcription factor SOX-2, ANOP3; Delta EF2a; MCOPS3 (Microphthalmia Syndromic type 3); SOX-2; SRY (sex determining region Y) box 2; SRY related HMG box 2; Transcription factor SOX-2; ysb

Summary

SOX2 is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach. SOX2 is necessary for regulating multiple transcription factors that affect Oct 3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct 3/4 expression. Reportedly, SOX2 is associated with aggressive phenotypes of breast, head and neck, gastric, colorectal, bladder, and small cell lung cancers. However, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and has been shown to be an independent favorable prognostic marker.

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