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Home >> Antibodies >> SMAD4 (Pancreatic Adenocarcinoma Marker)

SMAD4 (Pancreatic Adenocarcinoma Marker)

Mouse Monoclonal Antibody [Clone SMAD4/2524]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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SDS-PAGE Analysis Purified SMAD4 Mouse Monoclonal Antibody (SMAD4/2524). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

Deleted in Pancreatic Carcinoma 4 (DPC4); JIP; MAD homolog 4 (MADH4); Mothers against decapentaplegic homolog 4 (MADH4); Mothers against DPP homolog 4; MYHRS; SMAD4

Positive Control

Jurkat or A431 cells. Pancreatic Carcinoma

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating use Ab at 1-5ug/ml, order Ab without BSA)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human STAT6 protein

Cellular Localization

Cytoplasmic & Nuclear

Species Reactivity

Human. Others not known.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

61kDa

Specificity & Comments

Signaling from the ligand-activated membrane receptor serine/threonine kinases to nuclear targets is mediated by a set of evolutionarily conserved proteins known as DPC4. Upon ligand binding, the receptors of the TGF- family phosphorylate SMAD proteins (SMAD1 and SMAD2). These proteins then move into the nucleus, where they activate transcription. To carry out this function, the receptor activated SMAD1 and 2 require association with the product of deleted in pancreatic carcinoma, locus 4 (DPC4), also known as SMAD4. SMAD4/DPC4 is also implicated as a tumor suppressor, since it is inactivated in more than half of pancreatic carcinomas and to a lesser extent in a variety of other cancers. SMAD4 is absent in approximately 80% of pancreatic adenocarcinoma, but rarely in endometrial, colorectal, ovarian, lung, breast adenocarcinomas, and malignant melanom. SMAD4 is an important marker for confirming a diagnosis of pancreatic adenocarcinoma. Patients with pancreatic adenocarcinomas with SMAD4 protein expression had significantly longer survival than SMAD4 negative patients.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Lagna, G., et al. 1996. Nature 383: 832-836.

Bioinformatics

  •  Entrez Gene ID: 4089
  •  Gene Symbol: SMAD4
  •  SwissProt: Q13485
  •  Chromosome Location: 18q21.2
  •  Unigene: 75862