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Home >> Antibodies >> Pulmonary Surfactant-Associated Protein D (SFTPD)

Pulmonary Surfactant-Associated Protein D (SFTPD)

Mouse Monoclonal Antibody [Clone SFTPD/4363]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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Formalin-fixed, paraffin-embedded human lung stained with Surfactant Protein D Mouse Monoclonal Antibody (SFTPD/4363).

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Formalin-fixed, paraffin-embedded human lung stained with Surfactant Protein D Mouse Monoclonal Antibody (SFTPD/4363).

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SDS-PAGE Analysis Purified Surfactant Protein D Mouse Monoclonal Antibody (SFTPD/4363). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Pulmonary Surfactant-Associated Protein D Mouse Monoclonal Antibody (SFTPD/4363).

Product Details

Synonyms

COLEC7; Collectin-7; Lung surfactant protein D; PSP-D Surfactant protein D; PSPD; Pulmonary surfactant associated protein PSP-D; SFTP 4; SFTP4; SFTPD; SP-D; Surfactant associated protein pulmonary 4

Positive Control

Epithelial cells of the lung, skin, small intestine or bladder.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa241-336) ofhuman SFTPD protein (exact sequence is proprietary)

Cellular Localization

Secreted.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2c, kappa

Mol. Weight of Antigen

43kDa

Specificity & Comments

Pulmonary surfactant is primarily responsible for lowering the surface tension at the air-liquid interface in the alveoli, a process that is essential for normal respiration. Pulmonary surfactant is a mixture of phospholipids and proteins, including four distinct surfactant-associated proteins (SPs), SP-A, SP-B, SP-C, SP-D. SP-B and SP-C are predominantly hydrophobic proteins that associate with lipids to promote the absorption of surfactant phospholipids and to reduce the surface tension in the alveoli. SP-A and SP-D are large multimeric proteins belonging to the family of calcium-dependent lectins, designated Collectins, which contribute to the innate immune system. Both SP-A and SP-D have been shown to protect against microbial challenge through binding to the lipid components of the bacterial cell wall and facilitating the rapid removal of microbials.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Maitra, M., et al. 2010. Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress. J. Biol. Chem. 285: 22103-22113.

Bioinformatics

  •  Entrez Gene ID: 6441
  •  Gene Symbol: SFTPD
  •  SwissProt: P35247
  •  Chromosome Location: 10q22.3
  •  Unigene: 253495