Home >> Antibodies >> PAX8 (Renal Cell Marker)

PAX8 (Renal Cell Marker)

Recombinant Mouse Monoclonal Antibody [Clone rPAX8/3687]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

SDS-PAGE Analysis Purified PAX8 Recombinant Mouse Monoclonal Antibody (rPAX8/3687). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human thyroid stained with PAX8 Recombinant Mouse Monoclonal Antibody (rPAX8/3687).

SDS-PAGE Analysis Purified PAX8 Recombinant Mouse Monoclonal Antibody (rPAX8/3687). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human thyroid stained with PAX8 Recombinant Mouse Monoclonal Antibody (rPAX8/3687).

Product Details

Synonyms

Paired box 8; Paired box gene 8; paired box homeotic gene 8; Paired box protein Pax-8; Paired domain gene 8; PAX8

Positive Control

HeLa or Raji cells. Human renal cell carcinoma (RCC) or ovarian serous carcinoma.

Known Applications & Suggested Dilutions

IHC-P More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Synthetic peptide corresponding to the C-terminus of Human PAX8 protein

Cellular Localization

Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

62kDa

Specificity & Comments

Recognizes a protein of 62kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.