Formalin-fixed, paraffin-embedded human lobular breast carcinoma stained with GATA-3 Mouse Monoclonal Antibody (GATA3/6664) at 2ug/ml. HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.
SDS-PAGE Analysis Purified GATA-3 Mouse Monoclonal Antibody (GATA3/6664). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human lobular breast carcinoma stained with GATA-3 Mouse Monoclonal Antibody (GATA3/6664).
Formalin-fixed, paraffin-embedded human bladder stained with GATA-3 Mouse Monoclonal Antibody (GATA3/6664).
IHC analysis of formalin-fixed, paraffin-embedded human brain. Negative tissue control using GATA3/6664 at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
GATA-3 (GATA binding protein 3) is a member of the GATA family of transcription factors. This 50kDa nuclear protein regulates the development and subsequent maintenance of a variety of human tissues, including hematopoietic cells, skin, kidney, mammary gland, and the central nervous system. Among several other roles, GATA-3 involved in luminal cell differentiation in the mammary gland and appears to control a set of genes involved in the differentiation and proliferation of breast cancer. The expression of GATA-3 is associated with the expression of estrogen receptor-alpha (ER) in breast cancer. GATA-3 has been shown to be a novel marker for bladder cancer. The study demonstrated that GATA-3 stained 67% of urothelial Carcinomas, but none of prostate or renal carcinomas.