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Home >> Antibodies >> Cytokeratin 5 (KRT5) (Basal, Myoepithelial & Mesothelial Cell Marker)

Cytokeratin 5 (KRT5) (Basal, Myoepithelial & Mesothelial Cell Marker)

Mouse Monoclonal Antibody [Clone KRT5/2080]

Catalog #

Size

0.1 ml
0.5 ml

Price (USD)

199.00
459

Formulation

Culture Supernatant
Culture Supernatant

Catalog No

Size

0.1 ml
0.5 ml

Formulation

Culture Supernatant
Culture Supernatant

Price (USD)

199.00
459
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Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with Cytokeratin 5 (KRT5) Mouse Monoclonal Antibody (KRT5/2080).

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Formalin-fixed, paraffin-embedded human Basal Cell Carcinoma stained with Cytokeratin 5 (KRT5) Mouse Monoclonal Antibody (KRT5/2080).

Product Details

Synonyms

58kDa Cytokeratin; CK5; Cytokeratin-5; DDD1; Epidermolysis Bullosa Simplex 2 (EBS2); Keratin 5; Keratin, Type II Cytoskeletal 5; Keratin-5; KRT5; Type-II Cytoskeletal 5; Type-II keratin Kb5

Positive Control

MCF-7 or HeLa cells. Tonsil, Esophagus, Cervix or Urinary Bladder. Basal Cell or Squamous Cell Carcinoma.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1:50-1:100 for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human Cytokeratin 5 (KRT5) protein fragment (around aa 318-491) (exact sequence is proprietary)

Cellular Localization

Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

58kDa

Specificity & Comments

This MAb recognizes a protein of 58kDa, which is identified as Cytokeratin 5 (KRT5). This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Antibodies to KRT5 identify basal cells of squamous and glandular epithelia, myoepithelia, and mesothelium.Anti-cytokeratin 5 has been reported useful in the differential diagnosis of metastatic carcinoma in the pleura versus epithelioid mesothelioma. Almost all squamous cell carcinomas, half of transitional carcinomas, and many undifferentiated large cell carcinomas express.Anti-KRT5, along with anti-p63, affords a high sensitivity and specificity for squamous differentiation. Myoepithelial cells of the breast, glandular epithelia, and basal cells of the prostate are labeled with anti-KRT5.

Related Products



Tissue culture supernatant with 0.05% Azide. Contact us if you require it in a different format.

Key References

  1. Ordonez NG. Human Pathology. 2007; 38:1-16.

Bioinformatics

  •  Entrez Gene ID: 3852
  •  Gene Symbol: KRT5
  •  SwissProt: P13647
  •  Chromosome Location: 12q13.13
  •  Unigene: 433845
NBT02080