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Cytokeratin 5 (KRT5) (Basal, Myoepithelial & Mesothelial Cell Marker) Antibody [KRT5/2080]

In Stock
Catalog Number Formulation Size Price
3852-MSM1-CS0
Culture Supernatant
0.1ml
$229.00
3852-MSM1-CS1
Culture Supernatant
0.5ml
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

This MAb recognizes a protein of 58kDa, which is identified as Cytokeratin 5 (KRT5). This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Antibodies to KRT5 identify basal cells of squamous and glandular epithelia, myoepithelia, and mesothelium.Anti-cytokeratin 5 has been reported useful in the differential diagnosis of metastatic carcinoma in the pleura versus epithelioid mesothelioma. Almost all squamous cell carcinomas, half of transitional carcinomas, and many undifferentiated large cell carcinomas express.Anti-KRT5, along with anti-p63, affords a high sensitivity and specificity for squamous differentiation. Myoepithelial cells of the breast, glandular epithelia, and basal cells of the prostate are labeled with anti-KRT5.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG1 / Kappa
Gene Name
Positive Control
Cervix or Urinary Bladder. Basal Cell or Squamous Cell Carcinoma., Esophagus, MCF-7 or HeLa cells. Tonsil
Immunogen
Recombinant human Cytokeratin 5 (KRT5) protein fragment (around aa 318-491) (exact sequence is proprietary)
Alternate Names
Keratin, type II cytoskeletal 5, 58 kDa cytokeratin, Cytokeratin-5, Keratin-5, Type-II keratin Kb5, 58kDa Cytokeratin; CK5; Cytokeratin-5; DDD1; Epidermolysis Bullosa Simplex 2 (EBS2); Keratin 5; Keratin, Type II Cytoskeletal 5; Keratin-5; KRT5; Type-II Cytoskeletal 5; Type-II keratin Kb5

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
KRT5/2080
Chromosome Location
12q13.13
Mol. Weight of Antigen
58kDa

Key References

  • Ordonez NG. Human Pathology. 2007; 38:1-16.

PubMed Links

Storage & Stability

Store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

Tissue culture supernatant with 0.05% Azide. Contact us if you require it in a different format.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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