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Home >> Antibodies >> Cytokeratin 1 (Suprabasal Keratinocyte Marker)

Cytokeratin 1 (Suprabasal Keratinocyte Marker)

Mouse Monoclonal Antibody [Clone LHK1]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Skin stained with Cytokeratin 1 Mouse Monoclonal Antibody (LHK1).

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Formalin-fixed, paraffin-embedded human Cervix stained with Cytokeratin 1 Mouse Monoclonal Antibody (LHK1).

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SDS-PAGE Analysis Purified Cytokeratin 1 Mouse Monoclonal Antibody (LHK1). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

67kDa Cytokeratin; CK1; Cytokeratin-1; EHK1; Epidermolytic hyperkeratosis 1; EPPK; K1; Keratin Type II Cytoskeletal 1; Keratin-1; KRT1; KRT1A; NEPPK; Type II cytoskeletal 1; Type-II keratin Kb1

Positive Control

Skin or Cervix.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (0.1-0.2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

A 13-amino acid peptide (VRFVSTSYSGVTR) from the C-terminus of human KRT1 protein

Cellular Localization

Cytoplasmic

Species Reactivity

Human. Rat.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

67kDa

Specificity & Comments

Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Cytokeratin 1 is a hetero-tetramer of two type I as well as two type II keratins, keratin-10 (KRT10). Keratin 1 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epithelia. Mutations in keratin 1 cause epidermolytic hyperkeratosis.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Bloor et al. 2003. Am J Pathol. 162(3):963-75.
  2. Leigh et al. 1993. Br J Dermatol. 129(2):110-9.
  3. Waseem et al. 1999. J Invest Dermatol. 112(3):362-9.
  4. Machesney et al. 1998. Am J Pathol. 152(5):1133-41.

Bioinformatics

  •  Entrez Gene ID: 38748
  •  Gene Symbol: KRT1
  •  SwissProt: P04264
  •  Chromosome Location: 12q13.13
  •  Unigene: 80828
NBT01660