Recombinant Cytokeratin 1 (Suprabasal Keratinocyte Marker) [KRT1/8342R]

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Summary

Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Cytokeratin 1 is a hetero-tetramer of two type I as well as two type II keratins, keratin-10 (KRT10). Keratin 1 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epithelia. Mutations in keratin 1 cause epidermolytic hyperkeratosis.

Product Properties & Targets

Host
Rabbit
Species Reactivity
Human
Isotype
IgG, kappa
Cellular Localization
Cytoplasm.
Gene Name
KRT1
Positive Control
Human skin or cervix.
Immunogen
Recombinant full-length human KRT1 protein
Alternate Names
Keratin, type II cytoskeletal 1, 67 kDa cytokeratin, Cytokeratin-1, Hair alpha protein, Keratin-1, Type-II keratin Kb1, 67kDa Cytokeratin; CK1; Cytokeratin-1; EHK1; Epidermolytic hyperkeratosis 1; EPPK; K1; Keratin Type II Cytoskeletal 1; Keratin-1; KRT1; KRT1A; NEPPK; Type II cytoskeletal 1; Type-II keratin Kb1

Database Links

Entrez Gene ID
38748
Unigene
80828
SwissProt
P04264Human

Additional Information

Clone
KRT1/8342R
Human Gene Symbol
KRT1
Chromosome Location
12q13.13
Mol. Weight of Antigen
67kDa

Functions

  • May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.

Known Applications & Suggested Dilutions

  • Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Key References

  • Bloor et al. 2003. Am J Pathol. 162(3):963-75.
  • Waseem et al. 1999. J Invest Dermatol. 112(3):362-9.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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